1) All By Hand (I very likely won't be doing this)
2) Hand/Digital Hybrid
3) All Digital
My first inclination was to use some flavor of a hand and digital method (and I still might), but I came across this book on Amazon that describes an entirely digital process. I ordered the book, received it yesterday and went through a quick exercise that covers the rough sketch to inked drawing completely in a digital environment. This is my first experiment with some added color. On the plus side, the workflow is super streamlined even though I'm a little clumsy sketching on the Wacom tablet at the moment. On the downside, my Wacom skills need some work and I don't end up with nice pencil sketched pages like I would in a hand drawn process. Also, digital inking is also going to take a bit of experimentation in terms of brush settings, but I think with a little practice I can get my skills to an acceptable standard.
I still plan to try a hybrid flow (hand pencilled to digitally inked and colored) before I decide which way to go for the actual pages of my comic, but overall, I liked the all digital method and may end up employing it. Here's the drawing that I did.